Adoption of Abiraterone and Enzalutamide by Urologists

Androgen receptor aberrations and abiraterone/enzalutamide-resistant prostate cancer

Disclosures/Conflicts of Interest: GA has received honoraria, consulting fees or travel support from Astellas, Medivation, Janssen, Millennium Pharmaceuticals, Ipsen, Ventana, Bayer, Essa Pharma, Abbott Labs, Novartis, Veridex and Sanofi-Aventis, and grant support from Janssen, AstraZeneca, Innocrin and Arno. The Institute of Cancer Research developed abiraterone and therefore has a commercial ...

Current understanding of resistance to abiraterone  and enzalutamide in advanced prostate cancer.

Clinical activity of abiraterone acetate in patients with metastatic castration-resistant prostate cancer progressing after enzalutamide.

BACKGROUND Abiraterone acetate and enzalutamide both improve outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC). Optimal sequencing for these agents and whether cross-resistance occurs is unknown. METHODS Multicentre review of patients with mCRPC treated with abiraterone acetate and prednisone after progressing on enzalutamide. Primary objective was to determine...

AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer.

BACKGROUND The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutamide and abiraterone, but remains constitutively active as a transcription factor. We hypothesized that detection of androgen-receptor splice variant 7 messenger RNA (AR-V7) in circulating tumor cells from men with advanced prostate cancer would be associated with...

second language acquisition of telicity and aspect by persian learners of english

این تحقیق از دو قسمت اصلی تشکیل شده است: در قسمت اول فراگیری ختمیت به ویژه درک و تولید اینگونه جملات توسط فراگیران ایرانی زبان انگلیسی مورد بررسی قرار گرفته است. قضاوت تعدادی انگلیسی زبان بر روی این جملات نیز هدفی دیگر بود که در این رساله بررسی شده است. از موضوعات دیگر تفاوت بین نشانه های ختمیت در زبان انگلیسی و فارسی و تاثیر زبان اول فراگیران در درک و تولید اینگونه جملات است. در قسمت دوم استفا...